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The top immunotherapy drugs for mesothelioma as of 2023

Posted on: October 26, 2023 *Updated on: May 27, 2024

Immunotherapy has been gaining traction as a treatment option for various types of cancers, including mesothelioma. However, please note that this list provided and its current status might have changed after 2023, so it is crucial to consult the latest medical literature, clinical trials, and healthcare professionals for the most accurate and updated information.

Here’s a brief overview of some of the drugs:

Checkpoint Inhibitors

  1. Nivolumab (Opdivo): Targets PD-1, a protein on T cells that helps keep these cells from attacking other cells in the body.
  2. Ipilimumab (Yervoy): Targets CTLA-4, another protein on T cells, and is often used in conjunction with Nivolumab.
  3. Pembrolizumab (Keytruda): Another PD-1 inhibitor, used for a variety of cancers.
  4. Durvalumab (Imfinzi): Targets PD-L1, a protein often found on cancer cells.
  5. Atezolizumab (Tecentriq): Also targets PD-L1.

Monoclonal Antibodies

  1. Ramucirumab: Targets the VEGF receptor, blocking angiogenesis (the formation of new blood vessels) to starve tumors.
  2. LMB-100: An experimental drug that targets the mesothelin protein overexpressed in mesothelioma.
  3. Anetumab ravtansine: A targeted antibody-drug conjugate against mesothelin.

Adoptive Cell Therapy

  1. IcasM28z: A type of CAR T-cell therapy being explored for mesothelioma.

Anti-VEGF Treatment

  1. Bevacizumab (Avastin): Targets VEGF directly to inhibit angiogenesis.

Cancer Vaccine

  1. Galinpepimut-S: A vaccine that aims to stimulate the immune system to recognize and attack cancer cells.

Oncolytic Virus

  1. ONCOS-102: An oncolytic virus designed to selectively kill cancer cells.

It’s important to note that the effectiveness of these treatments can vary from patient to patient, and they can also come with their own set of side effects and risks. Combining different types of immunotherapy or using them in conjunction with other treatments like chemotherapy is an active area of research.

Consult a healthcare provider for personalized medical advice tailored to a patient’s specific condition.