Essential Questions to ask if you or a loved one has been diagnosed with Mesothelioma ***IMPORTANT***

Subtypes of Epithelial Mesothelioma

Posted on: February 7, 2024 *Updated on: May 27, 2024

Each subtype presents unique characteristics, affecting prognosis and treatment options. Here’s a brief overview of each subtype:

  1. Adenomatoid Mesothelioma: Represents approximately 6% of epithelioid pleural mesothelioma cases. This subtype is characterized by gland-like structures within the tumor.
  2. Cystic Mesothelioma: Typically benign and more commonly found in women, especially within the peritoneal cavity. Its benign nature distinguishes it from other, more aggressive forms of mesothelioma.
  3. Deciduoid Mesothelioma: Diagnosed in around 5% of mesothelioma patients, this subtype is known for its poor prognosis. The term “deciduoid” refers to its resemblance to decidua—the endometrial lining during pregnancy.
  4. Lymphohistiocytoid Mesothelioma: Extremely rare, accounting for less than 1% of cases. It’s characterized by a mixture of lymphocytes and histiocytes (immune cells), making it challenging to diagnose and treat.
  5. Small-cell Mesothelioma: An exceedingly rare subtype that can be easily confused with other small-cell cancers due to its microscopic appearance. Its rarity contributes to the difficulty in diagnosis and treatment.
  6. Solid Mesothelioma: This form appears as sheets or nests of cells, offering an average prognosis of just over a year. The “solid” pattern is indicative of the tumor’s density and cellularity.
  7. Tubulopapillary Mesothelioma: Features cube-shaped cells and is associated with an average prognosis of almost two years. The name reflects its microscopic pattern, consisting of tubular and papillary structures.
  8. Well-differentiated Papillary Mesothelioma: More commonly diagnosed in women, this subtype is characterized by slow growth and a tendency not to spread aggressively. Its well-differentiated cells indicate a lower grade and potentially better prognosis compared to other subtypes.

Identifying the specific subtype of epithelial mesothelioma through biopsy and histological examination is crucial for determining the most effective treatment strategy. Treatment customization based on the subtype can significantly impact the management and outcomes of the disease.