Essential Questions to ask if you or a loved one has been diagnosed with Mesothelioma ***IMPORTANT***

Stage 4 of Mesothelioma

Posted on: October 13, 2023 *Updated on: May 27, 2024

Here is an overview of stage 4 of mesothelioma:

  1. Local Metastasis: As you mentioned, mesothelioma predominantly metastasizes locally. For pleural mesothelioma (originating in the lining of the lungs), this means spread to other parts of the chest cavity and potentially to the lining of the heart (pericardium). For peritoneal mesothelioma (originating in the lining of the abdomen), this can mean spread throughout the abdominal cavity.
  2. Limited Curative Treatments: At stage 4, the primary goal is usually palliation (relief of symptoms) rather than cure. This is because the disease has progressed to a point where complete removal or eradication is very challenging or not possible.
  3. Palliative Care Options:
    • Chemotherapy: This can help shrink tumors and alleviate symptoms. The most common regimen for pleural mesothelioma includes pemetrexed and cisplatin.
    • Tumor Treating Fields (TTFields): This is a novel treatment approach that uses electric fields to disrupt tumor growth. It’s relatively new in the treatment of mesothelioma but has shown promise in some cases.
    • Immunotherapy: This helps the body’s immune system recognize and fight the cancer cells. Drugs like pembrolizumab and nivolumab have shown potential in some mesothelioma patients.
    • Radiation Therapy: While traditionally used in earlier stages or after surgery, it can also be used palliatively in stage 4 to help alleviate pain or other symptoms.
  4. Clinical Trials: These are indeed an avenue for some patients, especially when standard treatments are not effective. Clinical trials can offer access to experimental treatments that are not yet widely available. It’s crucial to discuss with a healthcare professional about the risks and benefits of participating in a trial.
  5. Support and Care: Beyond medical treatments, supportive care including pain management, respiratory therapy, dietary support, and counseling can be valuable for enhancing the quality of life for those with stage 4 mesothelioma.

It’s always essential for patients and their families to discuss treatment options and prognosis with their oncologist to make informed decisions tailored to the individual’s needs and preferences.