How Many Chemotherapy Treatments Are Needed for Mesothelioma?


The number of chemotherapy treatments needed for mesothelioma can vary significantly depending on several factors, including the patient’s overall health, the stage and type of mesothelioma, and how the disease responds to treatment. Chemotherapy is a cornerstone of mesothelioma treatment, often used to shrink tumors, alleviate symptoms, and improve life expectancy. It can be used alone or in combination with surgery and radiation therapy.

For mesothelioma, a common chemotherapy regimen involves the drugs pemetrexed (Alimta) and cisplatin. Some patients may undergo six cycles or more of this combination, but the exact number of cycles can vary. A “cycle” refers to a period of chemotherapy treatment followed by a period of rest to allow the body to recover. Each cycle typically lasts for a few weeks.

The decision on the number of cycles is made based on:

  • Treatment Goals: Whether chemotherapy is intended to cure the cancer (curative), make it smaller before surgery (neoadjuvant), help prevent it from coming back after surgery (adjuvant), or relieve symptoms and improve quality of life (palliative).
  • Response to Treatment: How well the cancer is responding to chemotherapy. If the tumors are shrinking and the patient is tolerating the treatment well, more cycles may be recommended.
  • Side Effects: The patient’s ability to tolerate the side effects of chemotherapy. If severe side effects occur, the treatment plan may need to be adjusted, which can include changing the chemotherapy drugs, altering the dosage, or adjusting the number of cycles.

Throughout the treatment, the medical team will closely monitor the patient’s response to chemotherapy and adjust the treatment plan as necessary. This can include conducting imaging tests (like CT scans) and blood tests to gauge the effectiveness of the chemotherapy and make adjustments to future cycles.

It’s essential for patients and their families to maintain open communication with their healthcare team, asking questions and expressing concerns about the treatment plan, including the expected number of chemotherapy cycles and potential side effects. This helps ensure that the treatment is as effective and tolerable as possible.